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Hydrochlorothiazide is a diuretic with antihypertensive propertiesIt acts by inhibiting the renal tubular reabsorption of sodium and chloride ionswhich are excreted with an accompanying volume of waterPotassium excretion is also promoted.

CyclosporineNeoralSandimmuneGengraftacrolimusPrograflithiumEskalithLithoBiddigoxinLanoxinsteroidsprednisone and othersa blood thinner such as warfarinCoumadinJantoveninsulin or oral diabetes medicationother blood pressure medicationsan ACE inhibitor such as benazeprilLotensinenalaprilVasoteclisinoprilPrinivilZestrilquinaprilAccuprilramiprilAltaceand otherscandesartanAtacandeprosartanTevetenirbesartanAvaprolosartanCozaarolmesartanBenicartelmisartanMicardisor valsartanDiovanor indomethacin or other NSAIDsnon-steroidal anti-inflammatory drugssuch as aspirinibuprofenAdvilMotrinnaproxenAleveNaprosynNaprelanTreximetcelecoxibCelebrexdiclofenacArthrotecCambiaCataflamVoltarenFlector PatchPennsaidSolarezeindomethacinIndocinmeloxicamMobicand others.

Treatment of hyperkalaemiaShould hyperkalaemia developdiscontinue treatment immediately andif necessarytake active measures to reduce the plasma potassium to normal.

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In some patients with compromised renal functione.gelderly patients or patients who are volume-depletedincluding those on diuretic therapywho are being treated with non-steroidal anti-inflammatory drugsincluding selective cyclooxygenase-2 inhibitorsthe co-administration of angiotensin II receptor antagonists or ACE inhibitors may result in a further deterioration of renal functionincluding possible acute renal failureThese effects are usually reversibleThereforethe combination should be administered with caution in patients with compromised renal function.

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