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Hydrochlorothiazide is a diuretic with antihypertensive propertiesIt acts by inhibiting the renal tubular reabsorption of sodium and chloride ionswhich are excreted with an accompanying volume of waterPotassium excretion is also promoted.

CyclosporineNeoralSandimmuneGengraftacrolimusPrograflithiumEskalithLithoBiddigoxinLanoxinsteroidsprednisone and othersa blood thinner such as warfarinCoumadinJantoveninsulin or oral diabetes medicationother blood pressure medicationsan ACE inhibitor such as benazeprilLotensinenalaprilVasoteclisinoprilPrinivilZestrilquinaprilAccuprilramiprilAltaceand otherscandesartanAtacandeprosartanTevetenirbesartanAvaprolosartanCozaarolmesartanBenicartelmisartanMicardisor valsartanDiovanor indomethacin or other NSAIDsnon-steroidal anti-inflammatory drugssuch as aspirinibuprofenAdvilMotrinnaproxenAleveNaprosynNaprelanTreximetcelecoxibCelebrexdiclofenacArthrotecCambiaCataflamVoltarenFlector PatchPennsaidSolarezeindomethacinIndocinmeloxicamMobicand others.

Treatment of hyperkalaemiaShould hyperkalaemia developdiscontinue treatment immediately andif necessarytake active measures to reduce the plasma potassium to normal.

Side effects that have been reported most frequently during controlled clinical trials with Moduretic.

In some patients with compromised renal functione.gelderly patients or patients who are volume-depletedincluding those on diuretic therapywho are being treated with non-steroidal anti-inflammatory drugsincluding selective cyclooxygenase-2 inhibitorsthe co-administration of angiotensin II receptor antagonists or ACE inhibitors may result in a further deterioration of renal functionincluding possible acute renal failureThese effects are usually reversibleThereforethe combination should be administered with caution in patients with compromised renal function.

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