Bupron tablets 150mg contain bupropion which is an antidepressant that is chemically unrelated to other known antidepressant agents, although it works at the level of the brain in a way similar to the class of antidepressants known as selective serotonin reuptake inhibitors ssri , which block the uptake by nerve cells of serotonin a neurotransmitter or brain chemical that allows nerve cells to communicate .
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15 Years of Clinical Experience With Bupropion HClFrom Bupropion to Bupropion SR to Bupropion XL.
You should not change your dose or stop using bupropion suddenlyunless you have a seizure while taking this medicineStopping suddenly can cause unpleasant withdrawal symptoms.
Bupropion may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be alert.
Bupropion appears to enhance monoaminergic neurotransmission via its effects on both the NE and DA transporterswith subsequent reuptake inhibition of these 2 neurotransmittersBupropion and 2 of its metaboliteshydroxybupropion and threohydrobupropionwere shown to decrease the uptake of NE and DA into rat and mouse synaptosomes9 Bupropion’s activity as a DA transporter inhibitor is further supported by a recent study showing approximately a 3-fold increase in expression of the immediate early gene c-fos in human DA transporter cellsandif coincubated with DAan attenuation of the DA-induced c-fos in human DA transporter cells14 Acute administration of bupropion reduces firing of brain stem NE and DA neuronsdata on fileGlaxoSmithKlineResearch Triangle ParkN.CAdditionallyfiring rates of NE neurons in the locus ceruleus are inhibited after acute bupropion administration9 Microdialysis studies following acute administration of bupropion demonstrate that extra-cellular NE and DA concentrations are increased in the nucleus accumbensdata on fileGlaxoSmithKlineResearch Triangle ParkN.CFurther evidence of the NDRI action of bupropion was found when administration of NEor DA-blocking drugs was shown to reduce the efficacy of bupropionand hydroxybupropionin animal models of depression15.
Bupropion is an antidepressant medication used to treat major depressive disorder and seasonal affective disorderThe Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.
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do not take decongestants eg, pseudoephedrine , stimulants, or diet pills while you are taking bupron sr without first checking with your doctor.