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Avoid administration of PPIs for longer than medically indicatedIf signs or symptoms consistent with CLE or SLE are noted in patients receiving Protonix I.Vdiscontinue the drug and refer the patient to the appropriate specialist for evaluationMost patients improve with discontinuation of the PPI alone in 4 to 12 weeksSerological testinge.gANAmay be positive and elevated serological test results may take longer to resolve than clinical manifestations.

Acute interstitial nephritis has been observed in patients taking PPIs including Protonix I.VAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue Protonix I.Vif acute interstitial nephritis developssee Contraindications4

There are no adequate and well-controlled studies in pregnant womenAdvise pregnant women of the potential risk of fetal harmBecause animal reproduction studies are not always predictive of human responsethis drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

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