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Concomitant use of CRIXIVAN with lovastatin or simvastatin is contraindicated due to an increased risk of myopathy including rhabdomyolysisCaution should be exercised if CRIXIVAN is used concurrently with atorvastatin or rosuvastatinTitrate the atorvastatin and rosuvastatin doses carefully and use the lowest necessary dose with CRIXIVANSee PRECAUTIONSDRUG INTERACTIONS

Over timeas new copies of HIV are made in the bodythe virus changes its structureThese changes are called mutations and can cause HIV to resist the effects of anti-HIV drugswhich means those drugs will no longer work for youCombining indinavir with at least two other anti-HIV drugs delays the development of drug resistance.

To explain how indinavir workswe need to first tell you some information about HIVWhen HIV infects a cellit takes control of that cellHIV then forces the cell to make many more copies of the virusTo make these copiesthe cell uses proteins called enzymesWhen the activity of these enzymes is reduced the production of HIV slows.

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