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To avoid drug-induced adrenal insufficiencysupportive dosage may be required in times of stresssuch as traumasurgeryor severe illnessboth during treatment with fludrocortisone acetate and for a year afterwards.
In larger dosesfludrocortisone acetate inhibits endogenous adrenal cortical secretionthymic activityand pituitary corticotropin excretionpromotes the deposition of liver glycogenandunless protein intake is adequateinduces negative nitrogen balance.
Dosage depends on the severity of the disease and the response of the patientPatients should be continually monitored for signs that indicate articulo 81. dosage adjustment is necessarysuch as remissions or exacerbations of the disease and stresssurgeryinfectiontraumasee WARNINGS and PRECAUTIONSGeneral
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