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Celexa and placebo groups were compared with respect to1mean change from baseline in vital signspulsesystolic blood pressureand diastolic blood pressureand2the incidence of patients meeting criteria for potentially clinically significant changes from baseline in these variablesThese fixime 400 mg tablet. analyses did not reveal any clinically important changes in vital signs associated with Celexa treatmentIn additiona comparison of supine and standing vital sign measures for Celexa and placebo treatments indicated that Celexa treatment is not associated with orthostatic changes.

Animal studies suggest that the abuse liability of Celexa is lowCelexa has not been systematically studied in humans for its potential for abusetoleranceor physical dependenceThe premarketing clinical experience with Celexa did not reveal any drug-seeking behaviorHoweverthese observations were not systematic and it is not possible to predicton the basis of this limited experiencethe extent to which a CNS-active drug will be misuseddivertedand/or abused once marketedConsequentlyphysicians should carefully evaluate Celexa patients for history of drug abuse and follow such patients closelyobserving them for signs of misuse or abusee.gdevelopment of toleranceincrementations of dosedrug-seeking behavior

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